Travelers are allowed for risk-free cancellation where they have to cancel their booking at least 24 hours before the flight ticket purchase. Then, the cancellation charges will not be applied. According to the American Airlines Cancellation Policy 1-800-364-9405, passengers are permitted to cancel their booking up to 2 hours before the departure. Travelers can only cancel their booking from the official website of American airlines helpline number 1-800-364-9405, or directly from the airport reservation counter of American airlines.